Endocrine Abstracts

Aim of the study: The aim of the study was to compare skin microvascular reactivity (MVR) with oxidative stress and metabolic parameters at fasting status and postprandially in patients with recently diagnosed type 2 diabetes.Methods: Twenty patients with type 2 diabetes (mean age 58±6 years, HbA1C 4.8±0.5%, diabetes duration 2.3±1.3 years, metformin treatment only) were included in the study. Blood samples were taken before and after 60, ...

Deiodinases (Dio1-3) are selenium-dependent enzymes that catalyze the reductive removal of iodine from iodothyronines. Depending on the substrate and the position of the iodine removed, deiodination can generate T3 from T4 or inactivate T3 and T4. Local expression of Dio can help to adjust the intracellular levels of T3 to the physiological needs of the organ without changing circulating T3 concentrations. It has been suggested that hepatic Dio1 generates circulating T3. Howev...

Literary data concerning quality of life in adult patients with classical form of 21 hydroxylase deficiency (21 CAH) are sparse and discrepant. Our aim thus was to explore quality of life in a group of young adults with 21CAH attending regularly tertiary reference care centre. We used WHOQuOL Bref questionnaire and we administered it to 45 21 CAH patients of age 28.6 ± 8 yrs and we compared the results with the data from 111 age matched controls from healthy Czech populat...

Introduction: Poorly differentiated carcinoma (PDTC) is an aggressive and rare form of thyroid carcinoma that originates from follicular cells and accounts for only 1-3 percent of all thyroid carcinomas diagnosed1. Most of the limited instances of PDTCs have been observed in older individuals. Instances in the pediatric population are exceedingly rare2.Case report: This report refers 17-year-old female, who presented moderate hirsut...

Histamine receptor antagonists seem to have effect on bone metabolism according to previous studies. We investigated the bone turnover in allergic children who were treated with H1 hisztamin receptor (H1R) antagonists.The biochemical bone turnover markers [β-CrossLapps (β-CTx), osteocalcin (OCN), β-CTx/OCN ratio], parathyroid hormone (PTH) and the 25-OH-vitamin D3 were determined in 37 H1R antagonist treated multiplex allergic c...

Background: Insulin tolerance test (ITT) is the gold-standard investigation in children with suspected growth hormone deficiency (GHD). Despite their benefits, ITTs are resource intensive, potentially dangerous and can result in unnecessary treatment due to false positive results in children that are at low risk for GHD.Methods: Retrospective analysis of all paediatric patients undergoing an ITT in two tertiary hospitals in the UK (centre A between 2017-...

Introduction: Hirata disease (or Insulin autoimmune syndrome) is characterized by the presence of high concentrations of insulin autoantibodies leading to hyperinsulinemic hypoglycemia in individuals with no history of prior exposure to exogenous insulin. Etiopathogenesis is not completely elucidated, it’s considered to result from the interaction of genetic predisposition and environmental triggers such as: medications (methimazole, carbimazole, alpha-lipoic acid, captop...

Background: Distinguishing pseudo-Cushing syndrome (PCS) from mild forms of Cushing’s disease (CD) is a challenge. The dexamethasone-Corticotropin Releasing Hormone test (dex-CRH) assumes that cortisol response to CRH is preserved in CD while suppressed in PCS after the low dose dexamethasone suppression test (LDDST). Methods: Persons with a suspicion of CD based on mild clinical features and a positive first-line screening test were included. They ...

We present a case report of a 56-year-old woman with MEN1 syndrome diagnosed at the age of 28 years. It was completely expressed by the set – insulinoma, prolactinoma and primary hyperparathyroidism. She underwent resection of 2/3 of the pancreas for symptomatic hypoglycaemia in the age of 28 years (1991). After two resections of parathyroid glands hypocalcaemia replacement was necessary. Prolactinoma was transiently treated with dopamine agonists. In the age of 45 years ...

Cadaveric islet transplantation can cure diabetes, however scarcity of donor islets means that this approach cannot be used for large-scale treatment. An alternative source of insulin-producing β-cells or whole islets would be step-wise in vitro differentiation from either human embryonic stem cells or induced pluripotent stem cells, which could be transplanted directly into patients. However, ‘β-like’ cells generated from existing differentiation ...